By way of Breda – Bergen-op-zoom – Goes

Take the A58 to Goes. Take the tunnel to Terneuzen. After the tunnel take the N61 to Breskens. At the round- about in Breskens you drive to the ferry, but on approaching the ferry, you take the road on your right. At the crossroads, you drive straight on. A few hundred metres further on, you will see the hotel on your left.   

By way of Bruges

Coming from Calais or Ostende, the easiest way to get to Breskens, is by way of Bruges. On leaving the motorway in Bruges, you take the N 31, and leave it in Dudzele, looking out for the indication Knokke-Heist. (The road has a terrible curb, but never mind !) Via Westkapelle, Sluis and Oostburg, you reach Breskens. On approaching the ferry to Flushing, you take the road on your right. At the crossroads, you drive straight on. A few hundred metres further on, you see Hotel de Milliano in all its splendour !

ANWB-Routeplanner (http://www.anwb.nl)

Should the ANWB Route Planner be available, fill in :
Destination : the Netherlands
Town : Breskens
Locality / zip code: Vlissingen-Breskens 

By way of Antwerp

Passed Antwerp, and having passed through the Kennedy tunnel, you take the second exit, direction Rotterdam/Bruges. You will reach the “Expressroad” N49, which you follow until the exit Watervliet/Kaprijke. You go by IJzendijke and at the traffic lights, you take left to Breskens. At the round-about in Breskens you drive to the ferry, but on approaching the ferry, you take the road on your right. At the crossroads, you drive straight on. A few hundred metres further on, you will see the hotel on your left.   

By way of Brussels

Should you come by way of Brussels, take the E40, direction Ostende. You leave the E40 in Aalter and you now follow the N44, direction Knokke-Heist. You leave the N44 direction Aardenburg. Via Oostburg, you reach Breskens. On approaching the ferry to Flushing, you take the road on your right. At the crossroads, you drive straight on. A few hundred metres further on, you see Hotel de Milliano on your left.